Neurofilament Light Chain (NfL) Test

Neurofilament Light Chain (NfL) Test
 
Neurofilament light chain (NfL) is a neuron-specific protein routinely released into the extracellular space. NfL test levels rise above baseline in response to neuronal injury and neurodegeneration. NfL has been widely studied and has demonstrated utility for various neurodegenerative diseases1
 
A rise in NfL is not specific for a specific disease factor and may be caused by both neurodegenerative diseases or a head impact during sports. Results should only be used in conjunction with other clinical information when evaluating patients with neurodegeneration. Due to a lack of specificity to a particular neurodegenerative disease, its role as a diagnostic marker is limited.
 
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