Individual Estradiol test. 
 
The symptoms of low estradiol in men may include:
mood swings and irritability
decreased bone density
reduced energy levels
weak skeletal muscles.
Low estradiol levels can negatively impact mood regulation by affecting the production and use of serotonin, a key neurotransmitter in mood control.
 
The symptoms of low estradiol in women may include:
Dry skin.
Tender breasts.
Weak or brittle bones.
Trouble concentrating.
Moodiness and irritability.
Vaginal dryness or atrophy.
Hot flashes and night sweats.
Irregular periods or no periods (amenorrhea).